What they don't know…

Derek has an interesting post up discussing the failure of the drug torcetrapib in clinical trials. I found these two paragraphs particularly interesting….

And that’s about where knowledge of this field stops among the general population, and I can understand why, because it gets pretty ferocious after that point. As with everything else in living systems, the closer you look, the more you see. There are, for starters, several subforms of HDL, the main alpha fraction and at least three others. And there are at least four types of alpha. At least sixteen lipoproteins, enzymes, and other proteins are distributed in various ratios among all of them. We know enough to say that these different HDL particles vary in size, shape, cholesterol content, origin, distribution, and function, but we don’t know anywhere near as much as we need to about the details. There’s some evidence that instead of raising HDL across the board, what you want to do is raise alpha-1 while lowering alpha-2 and alpha-3, but we don’t really know how to do that.

How does HDL, or its beneficial fraction(s) help against atherosclerosis? We’re not completely sure about that, either. One of the main mechanisms is probably reverse cholesterol transport (RCT), the process of actually removing cholesterol from the arterial plaques and sending it to the liver for disposal. It’s a compelling story, currently thought to consist of eight separate steps involving four organ systems and at least six different enzymes. The benefits (or risks) of picking one of those versus the others for intervention are unknown. For most of those steps, we don’t have anything that can selectively affect them yet anyway, so it’s going to take a while to unravel things. Torcetrapib and the other CETP inhibitors represent a very large (and very risky) bet on what is approximately step four.

Bureaucrats would be funny if they did not have so much power

Plumbing the depths has a new post up. Good news is that he has been down because business has been so good he did not have much time. But this lack of time has also caused him to have a little trouble with the powers that be….

The best part, as always, was dealing with the Inland Revenue. In all the huff and puff of plumbing I had forgotten to send in our annual PAYE return. Since we don’t pay PAYE I wasn’t overly concerned and, when I finally I remembered, I popped on-line and sent ‘the-powers-that-be’ a series of zero’s. Three weeks later I received a letter thanking me for sending them nothing but informing me that I had been fined £100 for sending them nothing far too late. Before I could get annoyed with this, I received another letter to tell me that the Revenue was going to pay me £200 for shunning the old paper-based system and not sending them anything ‘on-line’. This was very nice of them, so I rang up and asked if they could just deduct the fine from the reward and send me a cheque for £100. Surprisingly enough they didn’t have a problem with this and two weeks later I received the cheque. Then, just as I was beginning the think that the Inland Revenue wasn’t quite the bureaucratic monster everyone said it was, I received another, rather stroppy letter, pointing out that the Inland Revenue had had to send me a cheque for £100 and telling me to get my act together and make sure I didn’t over pay them again next year!

Rant of Week: 2/3/08-2/9/08

The hysteria on the on the political right that makes radical Islam out to be this great horrible threat is a dangerous thing. It is dangerous because it obscures the real problem. Even if radical Islam was wiped off the face of the earth, western society would still be in danger of collapsing. The problem is not that radical Islam is so dangerous but that western society is so rotten.

Popular conservative columnist Rod Dreher comes close to admitting as much in his rant entitled Dildos versus scimitars.

Essay of the Week: 2/3/08-2/9/08

The growing tension between Black and Hispanic communities has not received much attention in the main stream press. But it is a very real problem that could lead to lot of blood being shed in the years to come.

The Rainbow Coalition Evaporates by Steven Malanga is a good introduction to this issue. It is main problem is that Mr. Malanga is obviously not sympathetic to the immigrants, and that leads him to be unfair on a number occasions.

For example, he says….

A recent study by Harvard economist George Borjas and colleagues from the University of Chicago and the University of California estimates that immigration accounted for a 7.4 percentage-point decline in the employment rate of unskilled black males between 1980 and 2000.

Given that incarceration rates for black males also went up during that time period, I am highly skeptical of any study that can precisely pinpoint the porportion of the the fall in black male employment can be blamed on Hispanic immigrants. Even after you get out of jail, a record is a hard thing to get a job with.

You cannot blame Mr. Malanga for the conclusions of Borjas study of course. But Mr. Malanga does not seem inclined to even consider the alternate explanations.

But one Mr. Malanga’s unfairness is one of the things that helps makes “The Rainbow Coalition Evaporates” a good introduction to issue of Black and Hispanic tensions. After reading his piece, you will have no doubt about how many in the Black community have come view the immigration issue.

The Navy is going to use rail guns for ground support?

So the Navy has built a working rail gun….

Science got one step closer to science fiction Thursday morning, when the Navy used an electromagnetic railgun to fire a 7-pound slug at seven times the speed of sound.

The record-breaking shot, witnessed by a roomful of VIPs via remote camera at the Naval Surface Warfare Center, also moved the armed forces further down the road to a faster, safer, lighter, cheaper form of firepower.

So what are they going to use if for?

The Navy’s ultimate goal is a ship-mounted weapon capable of firing missiles 200 nautical miles in a six-minute arc into outer space and back to land, guided by GPS.

This dwarfs the range of the Navy’s current workhorse gun, the 5- inch MK 45, which shoots about 13 nautical miles.

The railgun uses electricity to propel its missiles, so they carry no fuel. The damage is caused purely by the kinetic energy of the missiles’ descent, which is projected to reach Mach 5, so they carry no warheads.

This means the missiles are cheaper. They are also smaller and safer, making them easier to store aboard ships and allowing for more variety in a vessel’s design.

For the Marines the gun would support, there are further benefits.

A ship carrying a rail gun would be able to begin bombarding the shore much sooner, far beyond radar range. It also would be able to fire more quickly.

The gun has a projected accuracy of 5 meters, which would minimize risk to Marines on the ground as well as any collateral damage.

I am sure that this gun has some uses as a ground support weapon. But I think that navy is being willfully blind here. A rail gun will only be an incremental improvements on the navy’s ability to blast ground targets. But it could change naval warfare completely. Just how would you defend a carrier from a rail gun?

Cruise missiles you can shoot down. In theory you can also shoot down ballistic missiles. But how are you going to stop an accurate rail gun that can fire from outside of radar range from sinking your carrier?

News to watch

We have not been keeping up on the news the last couple of days. Here are some things that you might have missed.

The first link comes from the Financial Times…..

The issue at stake revolves around so-called delinquency rates, the proportion of people who fall behind on their debt repayments. When American households have faced hard times in previous decades, they tended to default on unsecured loans such as credit cards and car loans first – and stopped paying their mortgage only as a last resort. However, in the last couple of years households have become delinquent on their mortgages much faster than trends in the wider economy might suggest. That is particularly true of the less creditworthy subprime borrowers. More­over, consumers have stopped paying mortgages before they halt payments on their credit cards or automotive loans – turning the traditional delinquency pattern on its head. As a result, mortgage lenders have started to face losses at a much earlier stage than in the past.

“In the past, if a household in America experienced financial problems it tended to go delinquent on its credit cards, but kept on paying its mortgage,” says Malcolm Knight, head of the Bank for International Settlements, the central banks’ bank. “Now what seems to be happening is that people who have outstanding mortgages that are greater than the value of their home, or have negative amortisation mortgages, keep paying off their credit card balances but hand in the keys to their house … these reactions to financial stress are not taken into account in the credit scoring models that are used to value residential mortgage-backed securities.”

Anecdotal evidence that this was going on has been piling up for awhile. Now it seems that it may be showing up in broader statistical samples. If this snowballs, housing prices could really drop.

Related to the above is this story from Bloomberg….

Standard & Poor’s said it cut or may reduce ratings on $534 billion of subprime-mortgage securities and collateralized debt obligations, the most sweeping action in response to rising home-loan defaults.

The downgrades may extend bank losses to more than $265 billion and have a “ripple impact” on the broader financial markets, S&P said in a statement today. The securities represent $270.1 billion, or 47 percent, of subprime mortgage bonds rated between January 2006 and June 2007. The New York-based ratings company also said it may cut 572 CDOs valued at $263.9 billion.

The reductions may increase losses at European, Asian and U.S. regional banks, credit unions and government-sponsored enterprises such as Fannie Mae, Freddie Mac and the 12 Federal Home Loan Banks, S&P said. Many of those institutions haven’t written down their subprime holdings to reflect a drop in market values and these downgrades may force them to recognize losses, S&P said.

The rating agencies have been downgrading things for awhile now. But doing half a trillion dollars worth in one whack still makes people sit up and take notice.

It is kind of funny that S&P is saying that the rating cut will force banks to recognize losses. The name of the game seems to be avoid having to face up to the facts at all costs. This from Naked Capitalism…..

But it seems that duplicity, um, creativity of various sorts is not only being encouraged but actually endorsed. First we had the Federal Home Loan Banks making massive loans to subprime lenders, particularly Countrywide. Now we have the SEC permitting subprime lenders to engage in what can only be described as misleading accounting.

If a mortgage servicer modifies a loan in a mortgage trust, an off balance sheet entity, in ways not comtemplated by the trust’s charter, the trust dissolves and the loans go back to the lender. But even though loan mods are often the best of the bad choices available when dealing with underwater borrowers, if the servicer does mods in a way that violates the trust charter, that means the poor overstrapped subprime lender has to take more assets onto its already not-so-hot balance sheet.

Enter the SEC with a magic wand. You can have your off balance sheet treatment, meddle with it like it really isn’t off balance sheet, but still keep your preferred accounting treatment.